Presentations: Musculoskeletal Systems Biology Lab

Peer-Reviewed Con­fer­ence Pro­ceed­ings and Abstracts

2014
58. Lugo J, Thompson MH, Huber P, Smith G, Holley A, Bain SD, Gardiner EM, KwonRY. Neuron subset specific PTEN deletion induces abnormal skeletal activity in mice. American Epilepsy Society Annual Meeting 2014. Oral Presentation
57. Kwon RY, Virdi A, Sumner DR. Cross-species transcriptomic analysis reveals conserved osteogenic signatures during zebrafish and rat bone regeneration. American Society for Bone and Mineral Research Annual Meeting 2014.
56. Kwon RY, Recidoro AM, Kaminsky W. Rotopol and microCT imaging in the regenerating zebrafish fin for BMD therapeutic discovery. American Society for Bone and Mineral Research Annual Meeting 2014.
55. Thompson MH, Huber P, Smith G, Holley A, Bain SD, Gardiner EM, Lugo J, KwonRY. Brain-specific PTEN deletion induces abnormal skeletal activity in mice. American Society for Bone and Mineral Research Annual Meeting 2014.
54. Worton LE, Park B, Recidoro AM, Gardiner EM, Kwon RY. Sensory neuron differentiation enhances osteoblast differentiation through soluble factors. American Society for Bone and Mineral Research Annual Meeting 2014.
53. Bain SD, Huber P, Kwon RY, Stoll L, Gross TS. Muscle, bone, and nerve differentially interact to achieve trabecular and cortical bone homeostasis. American Society for Bone and Mineral Research Annual Meeting 2014. Plenary Oral Presentation
52. Recidoro AM, Kaminsky W, Kwon RY. Bone mineralization in the regenerating zebrafish fin. 11th International Conference on Zebrafish Genetics and Development 2014.
51. Petrie TA, Strand NS, Recidoro AM, Gutgsell A, Kwon RY, Moon RT, Neuronal signaling is necessary for zebrafish appendage regeneration. 11th International Conference on Zebrafish Genetics and Development 2014. Plenary Oral Presentation
50.  Roof AC, Recidoro AM, Ausk BJ, Srinivasan S, Gross TS, Gardiner EM, Bain SD, Allan CH, Kwon RY, Chemical and mechanical nerve Impairment inhibit joint specification and bone formation in the regenerating zebrafish fin. Trans Orthopaedic Research Society 2014. Oral Presentation
49.  Ausk BJ, Worton LE, Threet D, Kwon RY, Bain SD, Gardiner EM, Gross TS, Transient muscle paralysis predisposes bone marrow to formation of giant osteoclasts. Trans Orthopaedic Research Society 2014.
48.  Stoll L, Huber P, Kwon RY, Threet D, Gross TS, Bain SD, Contralateral bone loss following ipsilateral nerve injury: Evidence for a neuronal skeletome. Trans Orthopaedic Research Society 2014.

2013
47. Huber P, Ausk BJ, Gar­diner EM, Bain SD, Srini­vasan S, Gross TS, Kwon RY, Systems-based dis­cov­ery in the zebrafish skele­ton using micro-computed tomog­ra­phy. 8th Euro­pean Zebrafish Meet­ing 2013. Ple­nary Oral Pre­sen­ta­tion
46. Kwon RY, Map­ping the skele­tal con­nec­tome: Emer­gent bone sig­na­tures fol­low­ing neu­ronal dys­func­tion in zebrafish. Sun Val­ley Work­shop 2013. Oral Pre­sen­ta­tion, Harold M. Frost Young Inves­ti­ga­tor Award
45. Reci­doro AM, Roof AC, Ausk BJ, Srini­vasan S, Gar­diner EM, Gross TS, Bain SD, Allan CH, Kwon RY, Neu­roskele­tal sig­nal­ing in the regen­er­at­ing zebrafish fin: Remote inhi­bi­tion of osteoblast func­tion via dis­rup­tion of cholin­er­gic sig­nal­ing. Amer­i­can Soci­ety for Bone and Min­eral Research Annual Meet­ing 2013. Ple­nary Poster and Oral Pre­sen­ta­tion
44. Huber P, Ausk BJ, Gar­diner EM, Bain SD, Srini­vasan S, Gross TS, Kwon RY, The skele­ton as a com­plex sys­tem: Emer­gent bone loss sig­na­tures fol­low­ing neu­ro­mus­cu­lar injury in zebrafish. Bio­med­ical Engi­neer­ing Soci­ety Annual Meet­ing 2013. Oral Pre­sen­ta­tion
43. Kwon RY, Threet D, Gar­diner EM, Wor­ton LE, Gross TS, Srini­vasan S, Timed admin­is­tra­tion of Cyclosporin A sup­ple­ments reveals mul­ti­ple routes to res­cu­ing loading-induced bone for­ma­tion at senes­cence. Bio­med­ical Engi­neer­ing Soci­ety Annual Meet­ing 2013. Oral Pre­sen­ta­tion
42. Wor­ton LE, Srini­vasan S, Kwon RY, Fluid dynamic gauging-based assays for high-throughput inves­ti­ga­tion of cel­lu­lar mechan­otrans­duc­tion. ASME Sum­mer Bio­engi­neer­ing Con­fer­ence 2013, 14394.
41. Downey LM, Gross TS, Kwon RY, Dif­fer­en­tial expres­sion of osteoac­tive myokines and muscle-enriched microR­NAs fol­low­ing tran­sient mus­cle paral­y­sis. Trans Orthopaedic Research Soci­ety 2013, 1440.
40. Srini­vasan S, Prasad J, Ausk BJ, Kwon RY, Wor­ton L, Gross TS, Bain SD, Gar­diner EM, Con­cur­rent opti­miza­tion of Cyclosporin A and mechan­i­cal load­ing iden­ti­fies mul­ti­ple optima to res­cue senes­cent bone adap­ta­tion. Trans Orthopaedic Research Soci­ety 2013, 1421.

2012
39. Kwon RY, Wor­ton LE, Srini­vasan S, Gross TS. Dif­fer­en­tial expres­sion of tran­scrip­tional clus­ters and recur­ring ERK1/2 acti­va­tion in bone cells sub­jected to rest-inserted dynamic fluid flow. Trans Orthopaedic Research Soci­ety 2012, 44. Oral Pre­sen­ta­tion
38. Wor­ton LE, Kwon RY, Gar­diner EM, Gross TS, Srini­vasan S. Cyclosporin A syn­er­gis­ti­cally enhances acute gene expres­sion and dif­fer­en­ti­a­tion in MC3T3-E1 cells sub­jected to dynamic fluid flow. Trans Orthopaedic Research Soci­ety 2012, 1381.
37. Sanyal A, Keav­eny T, Gupta A, Bayrak­tar HH, Kwon RY. Shear strength behav­ior of human tra­bec­u­lar bone. Trans Orthopaedic Research Soci­ety 2012, 125. Oral Pre­sen­ta­tion
36. Gross TS, Ausk BJ, Bain S, Downey L, Gard­ner E, Kwon RY, Wor­ton LE, Srini­vasan S. Mus­cle atro­phy enhances bone anabolism. Amer­i­can Soci­ety for Bone and Min­eral Research Annual Meet­ing 2012. Oral Pre­sen­ta­tion
35. Srini­vasan S, Threet D, Ausk BJ, Wor­ton LE, Kwon RY, Gar­diner EM, Bain S, Gross TS. Tai­lored drug-loading inter­ac­tions can res­cue bone adap­ta­tion at senes­cence. Amer­i­can Soci­ety for Bone and Min­eral Research Annual Meet­ing 2012.

2011
34. Kwon RY, Meays DR, Meilan AS, Mira­montes R, Kar­dos N, Yeh JC, Fran­gos JA. Osteocyte-independent mechan­otrans­duc­tion of inter­sti­tial fluid flow. Trans Orthopaedic Research Soci­ety 2011, 229. Oral Pre­sen­ta­tion
33. Wor­ton LE, Kwon RY, Gar­diner EM, Gross TS, Srini­vasan S. Fluid flow-induced early response genes are selec­tively altered by age. Amer­i­can Soci­ety for Bone and Min­eral Research Annual Meet­ing 2011.

2010
32. Kwon RY, Meays DR, Meilan AS, Mira­montes R, Kar­dos N, Yeh JC, Fran­gos JA. Osteocyte-independent mechan­otrans­duc­tion of inter­sti­tial fluid flow. Inter­na­tional Bone Fluid Flow Work­shop 2010. Oral Pre­sen­ta­tion, Young Inves­ti­ga­tor Award
31. Kwon RY, Meays DR, Meilan AS, Kar­dos NL, Fran­gos JA. Osteocyte-independent mechan­otrans­duc­tion of inter­sti­tial fluid flow. Amer­i­can Soci­ety for Bone and Min­eral Research Annual Meet­ing 2010, JBMR 25:S19. Oral Pre­sen­ta­tion, Young Inves­ti­ga­tor Award
30. Kwon RY, Meays DR, Kar­dos NL, Fran­gos JA. Reg­u­la­tion of energy metab­o­lism by osteo­cytes. Amer­i­can Soci­ety for Bone and Min­eral Research Annual Meet­ing 2010, JBMR 25:S220.
29. Kwon RY, Meays DR, Meilan AS, Kar­dos NL, Fran­gos JA. Osteocyte-independent mechan­otrans­duc­tion of inter­sti­tial fluid flow. Sun Val­ley Work­shop on Mus­cu­loskele­tal Biol­ogy 2010. Oral Pre­sen­ta­tion

2009
28. Kwon RY, Meays DR, Fran­gos JA. Microflu­idic enhance­ment of skele­tal fluid flow inhibits hindlimb unloading-induced bone loss in mice. Soci­ety for Phys­i­cal Reg­u­la­tion in Biol­ogy and Med­i­cine 2009. Oral Pre­sen­ta­tion
27. Kwon RY, Temiyasathit S, Tum­mala P, Quah CC, Jacobs CR. Adeny­lyl cyclase 6 and cAMP medi­ate pri­mary cilia-dependent mechanosens­ing in bone cells. Soci­ety for Phys­i­cal Reg­u­la­tion in Biol­ogy and Med­i­cine 2009. Oral Pre­sen­ta­tion
26. Kwon RY, Meays DR, Fran­gos JA. Microflu­idic enhance­ment of intramedullary pres­sure increases inter­sti­tial fluid flow and inhibits hindlimb unloading-induced bone loss in mice. Bio­med­ical Engi­neer­ing Soci­ety Annual Meet­ing 2009. Oral Pre­sen­ta­tion
25. Mel­chior, B, Kwon RY, Fran­gos JA. Inter-endothelial junc­tional incli­na­tion deter­mines flow direc­tion sense in endothe­lial cells. Bio­med­ical Engi­neer­ing Soci­ety Annual Meet­ing 2009. Oral Pre­sen­ta­tion
24. Kwon RY, Meays DR, Fran­gos JA. Microflu­idic enhance­ment of intramedullary pres­sure increases inter­sti­tial fluid flow and pro­tects against hindlimb unloading-induced bone loss in mice. Amer­i­can Soci­ety for Bone and Min­eral Research Annual Meet­ing 2009, JBMR 24:S101. Ple­nary Poster Pre­sen­ta­tion
23. Kwon RY, Temiyasathit S, Tum­mala P, Quah CC, Jacobs CR. Adeny­lyl cyclase 6 medi­ates pri­mary cilia-dependent changes in cyclic adeno­sine monophos­phate in response to dynamic fluid flow. ASME Sum­mer Bio­engi­neer­ing Con­fer­ence 2009.
22. Kwon RY, Meays DR, Fran­gos JA. Oscil­la­tory intramedullary pres­sure gen­er­ated by a novel microflu­idic sys­tem enhances inter­sti­tial trans­port and inhibits hindlimb unloading-induced bone loss in mice. New York Skele­tal Biol­ogy and Med­i­cine Con­fer­ence 2009.

2008
21. Kwon RY, Temiyasathit S, Tum­mala P, Quah CC, Jacobs CR. Adeny­lyl cyclase 6 medi­ates pri­mary cilia-regulated decreases in cAMP in bone cells exposed to dynamic fluid flow. Amer­i­can Soci­ety for Bone and Min­eral Research Annual Meet­ing, 2008, JBMR 23:S13. Oral Pre­sen­ta­tion
20. Kwon RY, Temiyasathit S, Tum­mala P, Quah CC, Jacobs CR. Inves­ti­gat­ing the role of pri­mary cilia in oscil­la­tory fluid flow-induced increases in intra­cel­lu­lar cAMP lev­els in MC3T3-E1 osteoblas­tic cells. Trans Orthopaedic Research Soci­ety 2008. Oral Pre­sen­ta­tion
19. Kwon RY, Temiyasathit S, Tum­mala P, Quah CC, Jacobs CR. Pri­mary cilia medi­ate intra­cel­lu­lar cAMP responses in bone cells exposed to dynamic fluid flow. ASME Sum­mer Bio­engi­neer­ing Con­fer­ence 2008, 192511. 2nd Place PhD Stu­dent Paper Com­pe­ti­tion
18. Kwon RY, Quah, CC, Jacobs CR. Com­pu­ta­tional mod­els of fluid flow through the osteo­cyte peri­cel­lu­lar space show sub­stan­tial load­ing on their cell bod­ies due to pres­sure gra­di­ents. Trans Orthopaedic Research Soci­ety 2008.

2007
17. Kwon RY, Jacobs CR, Lew AJ. A microstruc­turally informed model for the three-dimensional mechan­i­cal response of actin net­works. US National Con­gress on Com­pu­ta­tional Mechan­ics 2007. Oral Pre­sen­ta­tion
16. Kwon RY, Jacobs CR. Vis­coelas­tic­ity of bone cells exposed to fluid flow in vitro. Trans Orthopaedic Research Soci­ety 2007, 150. Oral Pre­sen­ta­tion
15. John­ston TR, Kwon RY, Jacobs CR. Side view char­ac­ter­i­za­tion of bone cells and their pri­mary cilia using adapted fluid flow cham­ber. Trans Orthopaedic Research Soci­ety 2007, 147. Oral Pre­sen­ta­tion
14. Clowes EJ, Kwon RY, Tum­mala P, Carter DR, Jacobs CR. Role of cytoskele­tal ten­sion in osteo­ge­n­e­sis due to load­ing induced fluid flow. Trans Orthopaedic Research Soci­ety 2007, 150. Oral Pre­sen­ta­tion
13. Kwon RY, Jacobs CR. Vis­coelas­tic­ity of bone cells exposed to fluid flow in vitro. Soci­ety for Phys­i­cal Reg­u­la­tion in Biol­ogy and Med­i­cine 2007. Oral Pre­sen­ta­tion, Best PhD Stu­dent Pre­sen­ta­tion
12. Doll JC, Har­jee N, Kle­jwa N, Kwon RY, Coulthard S, Pruitt BL. Bio­log­i­cal mea­sure­ments of C. Ele­gans touch sen­si­tiv­ity with micro­fab­ri­cated force sen­sors. Micro­TAS 2007, 0896.
11. Kle­jwa N, Har­jee N, Kwon RY, Coulthard S, Pruitt BL. Trans­par­ent SU-8 three-axis micro strain gauge force sens­ing pil­lar arrays with bio­log­i­cal appli­ca­tions. Trans­duc­ers 2007, AM0261.

2006
10. Kwon RY, Jacobs CR, Lew AJ. Homog­e­niza­tion of the actin cytoskele­ton: An approach based on finite ele­ment analy­sis, microstruc­ture char­ac­ter­i­za­tion and weighted prin­ci­pal com­po­nent analy­sis. Trans Orthopaedic Research Soci­ety 2006, 363. Oral Pre­sen­ta­tion
9. Kwon RY, Ayeni, OA, Jacobs CR. Inves­ti­ga­tion of the mechan­ics of bone cells exposed to fluid flow. Trans Orthopaedic Research Soci­ety 2006, 129. Oral Pre­sen­ta­tion
8. Kwon RY, Ayeni, OA, Jacobs CR. Mechan­ics of defor­ma­tion of osteoblas­tic cells exposed to steady and oscil­la­tory fluid flow. Soci­ety for Phys­i­cal Reg­u­la­tion in Biol­ogy and Med­i­cine 2006.
7. Kwon RY, Jacobs CR, Lew AJ. A novel approach to image based mod­el­ing of the actin cytoskele­ton. ASME Sum­mer Bio­engi­neer­ing Con­fer­ence 2006.

2005
6. Kwon RY, Abad-Manterola P, Lew AJ, Jacobs CR. Com­pu­ta­tional mod­el­ing of actin net­works and the cytoskele­ton. Soci­ety for Phys­i­cal Reg­u­la­tion in Biol­ogy and Med­i­cine 2005. Oral Pre­sen­ta­tion, Best PhD Stu­dent Pre­sen­ta­tion
5. Kwon RY, Jacobs CR, Lew AJ. Com­pu­ta­tional mod­el­ing of actin net­works. ASME Sum­mer Bio­engi­neer­ing Con­fer­ence 2005.
4. Kwon RY, Ayeni, OA, Jacobs CR. Mechan­ics of defor­ma­tion of bone cells. Bio­med­ical Com­pu­ta­tion at Stan­ford 2005.

2004
3. Kwon RY, Abad-Manterola P, Jacobs CR, Lew AJ. Com­pu­ta­tional mod­el­ing of actin net­works and the cytoskele­ton. Cal­i­for­nia Tis­sue Engi­neer­ing Annual Meet­ing 2004. Oral Pre­sen­ta­tion

2003
2. Bayrak­tar HH, Gupta A, Kwon RY, Keav­eny TM. Mul­ti­ax­ial fail­ure behav­ior of human femoral tra­bec­u­lar bone. Trans Orthopaedic Research Soci­ety 2003, 202. Oral Pre­sen­ta­tion

2002
1. Keav­eny TM, Bayrak­tar HH, Kwon RY. Shear load­ing is the weak­est link for femoral neck tra­bec­u­lar bone. Trans Orthopaedic Research Soci­ety 2002, 555.

National/International Invited Lec­tures

2. International Bone Fluid Flow Workshop, “Neuromuscular regulation of bone regeneration in zebrafish”, 2014
1. World Con­gress of Bio­me­chan­ics, “Neu­ro­mus­cu­loskele­tal sys­tems biol­ogy in zebrafish”, 2014

Invited Sem­i­nars

16. Brown Uni­ver­sity, Solid Mechan­ics Sem­i­nar Series, “From Fluid Flow to Zebrafish: Mus­cu­loskele­tal Dis­cov­ery Through Sys­tems Mechanobi­ol­ogy”, (to be pre­sented Decem­ber 2013)
15. Tulane Uni­ver­sity, Depart­ment of Bio­med­ical Engi­neer­ing Sem­i­nar Series, “From Fluid Flow to Zebrafish: Mus­cu­loskele­tal Dis­cov­ery through Mechanobi­ol­ogy”, 2013
14. Eli Lilly, Webi­nar, “Mus­cu­loskele­tal Dis­cov­ery in Zebrafish Through Sys­tems Biol­ogy”, 2013
13. Orthopaedic Work­shop, Uni­ver­sity of Wash­ing­ton, “Neu­ro­mus­cu­loskele­tal Dis­cov­ery Using Systems-Based Approaches in Zebrafish”, 2013
12. Uni­ver­sity of Wash­ing­ton, Kim Lab­o­ra­tory, “From Fluid Flow to Zebrafish: Mechanobi­o­log­i­cal Dis­cov­ery Through Systems-Based Approaches”, 2013
11. Uni­ver­sity of Ore­gon, Cresko Lab­o­ra­tory, “From Fluid Flow to Zebrafish: Mechanobi­o­log­i­cal Dis­cov­ery Through Systems-Based Approaches”, 2012
10. Benaroya Research Insti­tute, Amemiya Lab­o­ra­tory, “From Fluid Flow to Zebrafish: Ther­a­peu­tic Dis­cov­ery for Mus­cu­loskele­tal Dis­or­ders Through Mechanobi­ol­ogy”, 2012
9. Uni­ver­sity of Wash­ing­ton, Depart­ment of Orthopaedics and Sports Med­i­cine, “From Fluid Flow to Zebrafish: Ther­a­peu­tic Dis­cov­ery for Mus­cu­loskele­tal Dis­or­ders Through Mechanobi­ol­ogy”, 2012
8. Uni­ver­sity of Wash­ing­ton, Depart­ment of Mechan­i­cal Engi­neer­ing, “From Fluid Flow to Zebrafish: Ther­a­peu­tic Dis­cov­ery for Mus­cu­loskele­tal Dis­or­ders Through Mechanobi­ol­ogy”, 2012
7. Uni­ver­sity of Rochester, Depart­ment of Mechan­i­cal Engi­neer­ing, “Mechan­otrans­duc­tion of Inter­sti­tial Fluid Flow in Bone”, 2010
6. Rens­se­laer Poly­tech­nic Insti­tute, Depart­ment of Bio­med­ical Engi­neer­ing, “Mechan­otrans­duc­tion of Inter­sti­tial Fluid Flow in Bone”, 2010
5. Lehigh Uni­ver­sity, Depart­ment of Mechan­i­cal Engi­neer­ing and Mechan­ics, “Mechan­otrans­duc­tion of Inter­sti­tial Fluid Flow in Bone”, 2010
4. La Jolla Bio­engi­neer­ing Insti­tute, “Mechan­i­cal Behav­ior and Early Mol­e­c­u­lar Sig­nal­ing Dur­ing Mechan­otrans­duc­tion of Fluid Flow in Bone Cells”, 2008
3. Uni­ver­sity of Cal­i­for­nia San Diego, Car­ti­lage Tis­sue Engi­neer­ing Lab­o­ra­tory, “Mechan­i­cal Behav­ior and Early Mol­e­c­u­lar Sig­nal­ing Dur­ing Mechan­otrans­duc­tion of Fluid Flow in Bone Cells”, 2008
2. Uni­ver­sity of Cal­i­for­nia Berke­ley, Fletcher Lab­o­ra­tory, “Mechan­i­cal Behav­ior and Early Mol­e­c­u­lar Sig­nal­ing Dur­ing Mechan­otrans­duc­tion of Fluid Flow in Bone Cells”, 2008
1. Stan­ford Uni­ver­sity, Sim­bios Sem­i­nar, “Image-Based Mechan­i­cal Mod­el­ing of Cells”, 2008